What is Systemic lupus erythematosus (SLE) ?

Systemic lupus erythematosus is one of the forms of lupus erythematosus. It is an autoimmune disease in which the body’s immune system attacks its healthy tissues, usually all tissue systems of the body including the heart, kidneys, joints, lungs and even the blood cells.



Systemic lupus erythematosus usually comes with alternating severe and mild symptoms. Symptoms also vary among individuals. With treatment, people suffering with the disease can live a normal life.
Common symptoms include:

• Joint pain and swollen joints
• Severe fatigue
• A characteristic rash called butterfly rash that occurs on the nose and cheek
• Anaemia
• Hair loss
• Dysfunctional clotting system
• Headache
• Tingling sensation of the fingers in cold weather; the fingers can also turn white or blue; a condition referred to as Raynaud’s phenomenon

Some symptoms are particular to the body part being attacked, e.g., heart, skin, excretory and respiratory symptoms.



The causes of this disease can be broadly grouped into five categories:

• Genetics
•  Environment
•  Age
•  Ethnicity
•  Sex and hormones



It has been established that SLE runs in families of those with the disease. The specific gene responsible has not been identified, but some genes have been associated with SLE. These genes show polymorphism and have been closely linked. However, the role played, and the degree to which they contribute to the development of SLE is still unknown. Genes in the Human leukocyte antigen (HLA) family have been associated with SLE since they form part of the immune system.



Environmental factors that can lead to SLE include ultraviolet rays, use of certain medications, physical or emotional stress, viruses, and trauma.



Some age groups are more prone to SLE, though it can develop at any age. It is common in people of age 15-44. The disease is usually acute in younger people. Adolescents who are affected are more prone to the mucocutaneous manifestations of the disease than older patients. People affected at old age usually have high mortality rate due to the devastating manifestations associated with late onset.


Ethnic background

Statistics show that some ethnic groups are more prone to develop Lupus Erythematosus. Some ethnic groups also have better or worse prognosis. The disease most commonly affects people of Asian, African and Native American origin more than Caucasians; though it has a better prognosis in these ethnic groups than in Caucasians. Caucasians who have the disease usually die from complications of cardiovascular and respiratory symptoms and also malignancies.


Sex and hormones

SLE is found to affect females more than males. More so, females usually have serious complications than males, especially during pregnancy and menstruation. These findings have led to the belief that sex and hormones might influence the development of SLE.



The following procedures are used for diagnosing systemic lupus erythematosus:

• Blood tests: this includes full blood count, clotting profile and antibody tests
• Chest X-rays
• Urinalysis



SLE affects people in different ways; therefore treatment is more effective when it is individual-specific. However, there is no cure for SLE. Treatment is aimed at reducing or easing symptoms.

• Use of immunosuppressive drugs, e.g., corticosteroids and hydroxychloroquine. A new immunosuppressive drug, Belimumab, was approved by the U.S Food and Drug Administration in 2011 for the treatment of SLE.
•. Use of anti-inflammatory drugs for joint pain and stiffness.
• Use of steroid cream for rashes.
• Cognitive behavioral therapy (CBT) is employed by support groups and professional counsellors to help sufferers overcome depression, anxiety and stress, and to have a positive mental health, which will help them live their lives normally.


Regenerative Stem Cell Treatment and Possible Forecast

Mesenchymal stem cells are not detected by the immune system, making them very useful for treatment of autoimmune diseases such as systemic lupus erythematosus. In the research conducted, mesenchymal cells administered to SLE sufferers were to some extent recruited to areas where inflammation is taking place. In this way they helped with regenerating the damaged tissue.

What are the top Benefits of Non-surgical Regenerative Treatments?

With so many options out there, you may be wondering what benefits choosing Non-surgical Regenerative Treatments provides.  Over all Regenerative treatments are minimally invasive, non-surgical same day procedures with no risk of rejection, minimal recovery time and minimal worry. You are fully awake and ready to go home within a few hours after injections in the affected area.


Here are the top benefits to be aware of:

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Avoid surgery and its risks and many complications

Regenerative Therapy is a minimally invasive, non-surgical procedure, which gives patients an alternative to painful surgery and lengthy recovery. The procedure is performed in an outpatient setting and only takes a few hours. No general anaesthesia is required and most patients don’t need post-operative pain medication. Also, patients typically return to work within a week or two (unless told otherwise by the doctor) and they resume physical activity much faster than after invasive hip surgery.


Minimal post-procedural recovery time

One of the most time consuming factors of any injury is not always the treatment itself, but actually the recovery time. With Regenerative therapies, there is far less risk involved than surgery and recovery time is much shorter compared to surgery.


No use of general anaesthesia

Do you not like the way general anaesthesia makes your feel? Or do you simply get anxious at the thought of being put under? Regenerative therapy may be just what you need as it does not require the use of general anaesthesia. It provides a safe increasingly effective non-surgical alternative to treating medical conditions using the body’s own natural ability to repair itself without the use of medication.


Same day procedure

The best part, after comprehensive examination and review of your case, blood tests & radio-imaging scans are done to establish a baseline for your pre-existing condition, is that our Regenerative Therapies are a non-invasive treatment and an outpatient same day procedure, where the Consultant will decide which line of Regenerative Therapy is most suited to your case. In certain cases it may be a combination of more than one treatment protocol. For some patients however, the complete protocol is a series of injections in several treatment sessions.


Safe procedures with No risk of rejection and No communicable disease transmission

Your immune system has no reason to attack your cells and there is no risk of contracting a transmittable infectious disease from a donor patient also. In fact, studies thus far have indicated no safety issues with fat-derived autologous (from self) cells. Because they are your own cells, the risk of rejection is eliminated.

The increased risk of heart attack, as found to be associated with hip replacement surgery, is not present with Regenerative therapies, either. Like any procedure, there is a minute risk of infection at the sample collection and at the hip injection site. To minimize that risk the procedure is carried out under strict sterile conditions.

Am I a candidate for the Medica Institute Regenerative therapies?

In general, Regenerative Medica Institute Regenerative Therapies can be utilised by anyone, regardless of the age, race, or gender. However, in order to determine if you are a good candidate and will benefit the most from Regenerative treatment, you will need to schedule an appointment with our Clinic to have an assessment done by our Consultant, who will review your medical records and determine if you are a qualified candidate for our therapy. The choice of treatment is then at the discretion of the Consultant and is based on your unique case.


Regenerative Therapy may help patients who don’t respond to typical drug treatment, want to reduce their reliance on medication, or are looking for safe treatment alternatives. Regenerative treatments are not suitable for all conditions and all patients. The consultant will be able to advise if you are a suitable candidate.

Your first step to exploring your treatment options is scheduling a consultation with our Consultant. To do so call us on 020 8168 2000 or alternatively book a consultation online or request a call back today!